The knowledge base of scientific and technological archive is an important part of the technological innovation system. From the perspective of macrothinking, this article expounds the dynamic components of the knowledge base of scientific and technological archive based on four aspects: subject, object, technology, and market; and on the basis of it, in this article, the mechanisms of action of the synergy and nonequivalent dynamics is built between the dynamic elements of the knowledge base of scientific and technological archive : With knowledge “flow” passing through each stage of the knowledge base development as a starting point, a dynamic mechanism model of the knowledge base of scientific and technological archive was proposed and analyzed from a systematic perspective including knowledge acquisition, knowledge diffusion and knowledge integration respectively. The indepth explanations are provided on each aspect, and at the same time, the suggestions and countermeasures for the construction of the scientific and technical archive’ knowledge base are provided with pertinence and operability.