To explore thestatus of and relationship among the college students’learning stress, psychological resilience, and learning burnout, questionnaires were adopted to survey 541 college students of a university of Hunan Province. It was found thatgenerally college students suffered from moderate learning stress and learning burnout, their overall level of psychological resilience was sound, their learning stresscould positively predict their learning burnout, and psychological resilience was the intermediary variable of the impact of learning stresson learning burnout.