The traditional mode of university-enterprise cooperation puts the cooperation in the last link of the whole process of specialty construction and personnel training, which results only in the traditional weak links between university and enterprise. The innovation-driven specialty construction in university- enterprise cooperation should fully integrate the enormous innovation capability of universities and the demand of enterprises for innovation and establish a strong tie of specialty construction between universities and enterprises by involving the innovation demand and development of universities and enterprises into the whole process of the cooperation. This requires the cooperation of specialty construction to be based on these rules: the enterprises can participate in the whole process of specialty construction; the enterprises can share the benefits of cooperation; the resources can complement each other between universities and enterprises; cooperation intention and behavior of the universities and enterprises should be guided and inspired by evaluation.