From the perspective of system coupling, this paper constructs the coupling model and coupling coordination model of the complex system “cultural industry agglomeration-urbanization”, and firstly uses the panel data of 37 cities from three different economic regions to study the spatialtemporal variation of cultural industry agglomeration and urbanization. The study found that: ① the coupling degree in the Yangtze River economic region and the Bohai Sea economic region is better than the Pearl River economic region, which has been from the antagonistic stage to running in stage; ② although the coupling coordination degree in the three major economic zones have transited from low-grade coordination phase to moderate phase, but the fluctuation range is large, which shows the vulnerable coupling relationship between cultural industry agglomeration and urbanization; ③ the comprehensive order parameter of cultural industry agglomeration and urban shows significant regional differences, and cultural industry cluster development is relatively insufficient, lagging behind the urbanization development. Therefore, the relevant functional department should attach importance to the coupling of urbanization and cultural industry agglomeration in promoting the construction of urbanization.