The theory of alienated labor is the important content and core viewpoint of Marx’s early classic text Manuscript of Economics and Philosophy in 1844. The critical investigation of the abstract nature of national economics, the critical inheritance of Hegel’s dialectical alienation thought and Feuerbach’s humanistic thought, are the generation logic of Marx’s alienated labor theory. Marx elaborated the four-fold regulations of alienated labor under capitalist private ownership, which are the overall alienation of labor and products, labor activities, human nature, and the relationship between people. On that basis, Marx points out that communism is the inevitable way to treat alienated labor and realize human liberation. A comprehensive understanding and in_x005fdepth grasp of Marx’s theory of alienated labor has important practical implications. It is a powerful weapon for us to better understand the development of contemporary capitalist society. And it has important guiding signifi? cance for better adhering to and implementing the people-centered development thinking and meeting the people’ s needs for a better life.